Insulin signaling pathway
| PAG Title | Insulin signaling pathway |
| PAG ID | WAG001214 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kise (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kise (PI3K). PI3K activates 3-phosphoinositide-dependent protein kise 1 (PDK1), which activates Akt, a serine kise. Akt in turn deactivates glycogen synthase kise 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR. |
| Species | Homo sapiens |
| nCoCo Score | 1,937 |
| Base PAG ID | WAG001214 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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